研究成果については大阪大学研究者総覧(外部リンク)からも閲覧できます。

プレスリリース一覧

うつ病の重症度、および「死にたい気持ち(自殺念慮)」に関連する血中代謝物を同定 ― うつ病の客観的診断法開発への応用に期待 ―
(2016年12月14日)
治療抵抗型統合失調症の治療薬の作用機序の一端を発見 ― 治療反応性を予測するバイオマーカーの開発に期待 ―
(2016年10月27日)
統合失調症の認知・社会機能を予測する手法を開発 ― 患者の社会復帰を支えるツールとして期待 ―
(2016年8月26日)
精神科医療の普及と教育に対するガイドラインの効果に関する研究を開始〜精神科医への教育を行い、よりよい医療の実践に大きく前進〜
(2016年5月26日)
細胞内タンパク質輸送の異常が記憶・学習等の脳高次機能に障害を与える分子メカニズムを発見―精神疾患の新しい薬の開発に期待―
(2016年2月2日, Nature Communications)
クロザピンがもつ副作用のリスク遺伝子を同定-患者への安心・適切な治療の足がかり-
(2016年1月26日, Biological Psychiatry)
統合失調症の大脳皮質下領域の特徴を発見 淡蒼球の体積に左右差がある
(2016年1月15日, Molecular Psychiatry)
新しい統合失調症の解析手法を開発〜医者の診断を補完する自動診断システムの開発に期待〜
(2015年7月24日, 神経科学会、NICT共同)
統合失調症の認知機能に関与する遺伝子ネットワークを同定 - 統合失調症の原因解明や薬剤の開発に期待 -
(2014年12月16日, Schizophrenia Bulletin)
統合失調症を判別する眼球運動特徴の発見 - 統合失調症の客観的補助診断法の開発に期待 -
(2014年11月5日, Schizophrenia Research)
学習能力の発達を調節するタンパク質を発見!〜成長期でのはたらきが、おとなの脳機能を左右する〜
(2014年8月18日, Cell Report)
統合失調症の認知機能障害に関与する遺伝子を発見
(2013年5月24日, American Journal of Psychiatry)

研究成果一覧

2017年

  1. Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H. High-speed and scalable whole-brain imaging in rodents and primates. Neuron, 94:1085?1100, 2017.6 http://dx.doi.org/10.1016/j.neuron.2017.05.017
  2. Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, *Hashimoto R. Estimated cognitive decline in patients with schizophrenia: a multi-center study. Psychiatry Clin Neurosci, 71(5):294-300, 2017.5 doi: 10.1111/pcn.12474.
  3. Isomura S, Hashimoto R, Nakamura M, Yamashita F, Jimbo S, Hirano Y, Yamamori H, Fujimoto M, Yasuda Y, Mears R, Onitsuka T. Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia. nature partner journal Schizophrenia, 3(1):3:1-4, 2017.5 doi:10.1038/s41537-016-0008-y
  4. Walton E, Hibar DP, van Erp TGM, Potkin SG, Roiz-Santianez R,Crespo-Facorro B, Suarez-Pinilla P, Van Haren NEM,de Zwarte SMC, Kahn RS, Cahn W, Doan NT, Jorgensen KN,Gurholt TP, Agartz I, Andreassen OA, Westlye LT, Melle I, Berg AO, Morch-Johnsen L, Farden A, Flyckt L, Fatouros-Bergman H, Karolinska Schizophrenia Project Consortium (KaSP), Jonsson EG, Hashimoto R, Yamamori H, Fukunaga M, Preda A, De Rossi P, Piras F, Banaj N, Piras F, Ciullo V, Spalletta G, Gur RE, Gur RC, Wolf DH, Satterthwaite TD, Beard LM, Sommer IE, Koops S, Gruber O, Richter A, Kramer B, Kelly S, Donohoe G, McDonald C, Cannon DM, Corvin A, Gill M, Di Giorgio A, Bertolino A, Lawrie S, Nickson T, Whalley HC, Neilson E, Calhoun VD, Thompson PM, Turner JA, Ehrlich S. Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA-Schizophrenia consortium. Acta Psychiatr Scand, 135(5):439-447, 2017.5 doi: 10.1111/acps.12718
  5. Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Ikeda M, Sora I, Iwata N, *Hashimoto R. Optimizing Outcomes in Clozapine Rechallenge Following Neutropenia Using Human Leukocyte Antigen Typing: A Case Report. Psychiatry Clin Neurosci, 71(4):289-290, 2017.4 doi: 10.1111/pcn.12505
  6. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Effect of clozapine on DNA methylation in peripheral leukocytes frompatients with treatment-resistant schizophrenia. Int J Mol Sci, 18(3):632, 2017.3 doi:10.3390/ijms18030632
  7. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, *Hashimoto R. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Schizophr Res, 181:75-82, 2017.3 http://dx.doi.org/10.1016/j.schres.2016.10.012
  8. Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato T, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami S, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T. Microglia-derived neuregulin expression in psychiatric disorders. Brain Behav Immun, 61:375-385, 2017.3 doi: 10.1016/j.bbi.2017.01.003
  9. Sakamoto Y, Kioka H, Hashimoto R, Takeda S, Ohtani T, Yamaguchi O, Wasa M, Nakatani S, Sakata Y. Cardiogenic shock caused by left mid-ventricular obstruction in a patient with anorexia nervosa; A novel cardiac manifestation of refeeding syndrome. Nutrition, 35:148-150, 2017.3 doi: 10.1016/j.nut.2016.12.017
  10. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry, 22(3):430-440, 2017.3 doi: 10.1038/mp.2016.88
  11. Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Kasai K, *Hashimoto R. Eye movement as a biomarker of schizophrenia:Using an integrated eye movement score. Psychiatry Clin Neurosci, 71(2):104-114, 2017.2 doi:10.1111/pcn.12460
  12. Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivieres S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CR, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jorgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Munoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LM, Oosterlaan J, Papmeyer M, Pirpamer L, Putz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santianez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Samann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJ, De Geus EJ, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernandez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Goring HH, Green RC, Gruber O, Gudnason V, Guelfi S, Haberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, (332名中201番目) Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Pol HE, Ikeda M, Jack CR Jr, Jenkinson M, Johnson R, Jonsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Muhleisen TW, Muller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernandez MC, Van der Brug M, van der Lugt A, van der Wee NJ, Van Haren NE, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Volzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA. Novel genetic loci associated with hippocampal volume. Nat Commun, 18;8:13624, 2017.1 doi: 10.1038/ncomms13624.
  13. Thompson P, Andreassen O, Arias-Vasquez A, Bearden C, Boedhoe P, Brouwer R, Buckner R, Buitelaar J, Bulaeva K, Cannon D, Cohen R, Conrod P, Dale A, Deary I, Dennis E, de Reus M, Desrivieres S, Dima D, Donohoe G, Fisher Simon, Fouche JP, Francks C, Frangou S, Franke B, Ganjgahi H, Garavan H, Glahn D, Grabe H, Guadalupe T, Gutman B, Hashimoto R, (71名中31番目)Hibar D, Holland D, Hoogman M, HulshoffPol H, Hosten N, Jahanshad N, Kelly S, Kochunov P, Kremen W, Lee P, Mackey S, Martin N, Mazoyer B, McDonald C, Medland S, Morey R, Nichols T, Paus T, Pausova Z, Schmaal L, Schumann G, Shen L, Sisodiya S, Smit D, Smoller J, Stein D, Stein J, Toro R, Turner J, van den Heuvel M, van den Heuvel O, van Erp T, van Rooij D, Veltman D, Walter H, Wang Y, Wardlaw J, Whelan C, Wright M, Ye J, for the ENIGMA Consortium. ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide. NeuroImage, 145(Pt B):389-408, 2017.1 doi: 10.1016/j.neuroimage.2015.11.057

2016年

  1. Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Takeda M, Hashimoto R. Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. Psychiatry Res,(in press)
  2. Thompson P, Andreassen O, Arias-Vasquez A, Bearden C, Boedhoe P, Brouwer R, Buckner R, Buitelaar J, Bulaeva K, Cannon D, Cohen R, Conrod P, Dale A, Deary I, Dennis E, de Reus M, Desrivieres S, Dima D, Donohoe G, Fisher Simon, Fouche JP, Francks C, Frangou S, Franke B, Ganjgahi H, Garavan H, Glahn D, Grabe H, Guadalupe T, Gutman B, Hashimoto R, (71名中31番目)Hibar D, Holland D, Hoogman M, HulshoffPol H, Hosten N, Jahanshad N, Kelly S, Kochunov P, Kremen W, Lee P, Mackey S, Martin N, Mazoyer B, McDonald C, Medland S, Morey R, Nichols T, Paus T, Pausova Z, Schmaal L, Schumann G, Shen L, Sisodiya S, Smit D, Smoller J, Stein D, Stein J, Toro R, Turner J, van den Heuvel M, van den Heuvel O, van Erp T, van Rooij D, Veltman D, Walter H, Wang Y, Wardlaw J, Whelan C, Wright M, Ye J, for the ENIGMA Consortium. ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide. NeuroImage (in press, e-pub ahead of print) doi: 10.1016/j.neuroimage.2015.11.057
  3. Saito T, Ikeda M, Mushiroda T, Ozeki T, Kondo K, Shimasaki A, Kawase K, Hashimoto S, Yamamori H, Yasuda Y, Fujimoto M, Ohi K, Takeda M, Kamatani Y, Numata S, Ohmori T, Ueno S, Makinodan M, Nishihata Y, Kubota M, Kimura T, Kanahara N, Hashimoto N, Fujita K, Nemoto K, Fukao T, Suwa T, Noda T, Yada Y, Takaki M, Kida N, Otsuru T, Nurakami M, Takahashi A, Kubo M, *Hashimoto R, Iwata N. Pharmacogenomic study of clozapine-induced agranulocytosis/granulocytopenia in a Japanese population. Biol Psychiatry, (in press, e-pub ahead of print) doi: 10.1016/j.biopsych.2015.12.006
  4. Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, Yasuda Y, Fujimoto M, Watanabe Y, Yahata N, Nemoto K, Hibar D, van Erp T, Fujino H, Isobe M, Isomura S, Natsubori T, Narita H, Hashimoto N, Miyata J, Koike S, Takahashi T, Yamasue H, Matsuo K, Onitsuka T, Iidaka T, Kawasaki Y, Yoshimura R, Watanabe Y, Suzuki M, Turner J, Takeda M, Thompson P, Ozaki N, Kasai K, *Hashimoto R, COCORO. Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry (in press, e-pub ahead of print) doi: 10.1038/mp.2015.209
  5. Ohi K, Kikuchi M, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fujino H, Miura K, Fukunaga M, Nakaya A, Iwata N, Hashimoto R. Polygenetic Components for Schizophrenia, Bipolar Disorder and Rheumatoid Arthritis Predict Risk of Schizophrenia. Schizophr Res, 175:226-229, 2016.8 doi: 10.1016/j.schres.2016.04.009
  6. Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama M, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T. A significant causal association between C-reactive protein levels and schizophrenia. Sci Rep, 6:26105, 2016.5 doi:10.1038/srep26105
  7. Prosselkov P, Hashimoto R, Polygalov D, Ohi K, Zhang Qi, McHugh T, Takeda M, Itohara S. Cognitive enophenotypes of modern and extinct hominins associated with NTNG gene paralogs. Biomedical Genetics and Genomics, 1(1): 5-13, 2016.4 doi: 10.15761/BGG.1000103
  8. Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H. De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ. J Mol Psychiatry, 4:1, 2016.4 doi: 10.1186/s40303-016-0016-x.
  9. van Erp T, Hibar D, Rasmussen J, Glahn D, Pearlson G, Andreassen O, Agartz I, Westlye L, Haukvik UK, Dale A, Melle I, Hartberg C, Gruber O, Krämer B, Zilles D, Donohoe G, Kelly S, McDonald C, Morris D, Cannon DM, Corvin A, Machielsen M, Koenders L, de Haan L, Veltman D, Satterthwaite T, Wolf D, Gur RC, Gur RE, Potkin S, Mathalon D, Mueller B, Preda A, Macciardi F, Ehrlich S, Walton E, Hass J, Calhoun V, Bockholt H, Sponheim S, Shoemaker J, van Haren N, Hulshoff Pol H, Ophoff R, Kahn RS, Roiz-Santiañez R, Crespo-Facorro B, Wang L, Alpert K, Jonsson E, Dimitrova R, Bois C, Whalley H, McIntosh A, Lawrie S, Hashimoto R, (58名中56番目)Thompson P, Turner J, for the ENIGMA Schizophrenia Working Group, Subcortical Brain Volume Abnormalities in 2,028 Individuals with Schizophrenia and 2,540 Healthy Controls via the ENIGMA Consortium. Molecular Psychiatry, 21(4):547-553, 2016.4 doi: 10.1038/mp.2015.63
  10. Higashiyama R, Ohnuma T, Takebayashi Y, Hanzawa R, Shibata N, Yamamori H, Yasuda Y, Kushima I, Aleksic B, Kondo K, Ikeda M, Hashimoto R, Iwata N, Ozaki N, Arai H. Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. Am J Med Genet B Neuropsychiatr Genet, 171(3):447-457, 2016.4 doi: 10.1002/ajmg.b.32426
  11. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato C, Benabarre A, Bengesser S, Bhattacharjee A.K., Biernacka J.M., Birner A, Brichant-Petitjean C, Bui E.T., Cervantes P, Chen G, Chen H, Chillotti C, Cichon S, Clark S.R., Colom F, Cousins D, Cruceanu C, Czerski P.M., Dantas C.R., Dayer A, Etain B, Falkai P, Forstner A.J., Frisen L, Fullerton J.M., Gard S, Garnham J.S., Goes F.S., Grof P, Gruber O, Hashimoto R, (124名中40番目) Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jimenez E, Kahn J, Kassem L, Kittel-Schneider S, Kliwicki S, Konig B.B., Kusumi I, Lackner N, Laje G, Landen M, Lavebratt C, Leboyer M, Leckband S.G., Jaramillo C.L., MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy M.J., McElroy S, Mitjans M, Francis M. Mondimo F.M., Monteleone P, Nievergelt C.M., Nothen M.M., Osby U, Ozaki N, Perlis R.H., Pfennig A, Reich-Erkelenz D, Rouleau G.A., Schofield P.R., Schubert K.O., Schweizer B.W., Seemuller F, Severino G, Shekhtman T, Shilling P.D., Shimoda K, Simhandl C, Slaney C.M., Smoller J.W., Squassina A, Stamm T, Stopkova P, Tighe S.K., Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young L.T., Zandi P.P., Potash J.B., DePaulo J.R., Bauer M, Reininghaus E, Novak T, Aubry J.M., Maj M., Baune B.T., Mitchell P.B., Vieta E, Frye M.A., Rybakowski J.K., Kuo P, Kato T, Grigoroiu-Serbanescu M, Reif A, Zompo M.D., Bellivier F, Schalling M, Wray N.R., Kelsoe J, Alda M, Rietschel M, McMahon F.J., Schulze T.G. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet, 12;387(10023):1085-93, 2016.3 doi:org/10.1016/S0140-6736(16)00143-4
  12. *Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H. Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. Journal of Human Genetics, 61(3):199-206 , 2016.3 doi: 10.1038/jhg.2015.141
  13. Kamada Y, Hashimoto R, Yamamori H, Yasuda Y, Takehara T, Fujita Y, Hashimoto K, Miyoshi E. Impact of plasma transaminase levels on the peripheral blood glutamate levels and memory functions in healthy subjects. BBA Clin, 5:101-107, 2016.3 doi:10.1016/j.bbacli.2016.02.004
  14. Yasuda Y, Hashimoto R, Nakae A, Kang H, Ohi K, Yamamori H, Fujimoto M, Hagihira S, Takeda M. Sensory cognitive abnormalities of pain in autism spectrum disorder: a case control study. Ann Gen Psychiatry,15:8, 2016.3 doi:10.1186/s12991-016-0095-1
  15. Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, *Hashimoto R, Takeda M, Imura O. Predicting employment status and subjective quality of life in patients with schizophrenia. Schizophrenia Research: Cognition, 3:20-25, 2016. 3 doi:10.1016/j.scog.2015.10.005
  16. *Nakazawa T, *Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, *Kano M. Emerging Roles of ARHGAP33 in Intracellular Trafficking of TrkB and Pathophysiology of Neuropsychiatric Disorders. Nat Commun, 7:10594, 2016.2 doi: 10.1038/ncomms10594
  17. Gould T.D., Hashimoto R, Schulze T.G. Going longitudinal in biological psychiatric research: all things considered. Neurosci Res, 102(2016):1-3, 2016.1 doi:10.1016/j.neures.2015.12.012

2015年

  1. Yamamori H, Ishima T, Yasuda Y, Fujimoto M, Kudo N, Ohi K, Hashimoto K, Takeda M, Hashimoto R. Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanesepopulation. Neurosci Lett, 612:167-171, 2015.12 doi: 10.1016/j.neulet.2015.12.019.
  2. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito Y, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Molecular Brain, 20;8(1):50, 2015.8 doi: 10.1186/s13041-015-0142-x.
  3. Ohi K, *Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M. Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. Schizophrenia Bulletin, 41(4):909-18, 2015.7 doi: 10.1093/schbul/sbu171.
  4. Shirai Y, Fujita Y, Hashimoto R, Ohi K, Yamamori H, Yasuda Y, Ishima T, Suganuma H, Ushida Y, Takeda M, Hashimoto K. Dietary intake of sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood. PLoS One, 24;10(6):e0127244, 2015.6 doi: 10.1371/journal.pone.0127244.
  5. Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, Hashimoto R, Imoto I, Ohmori T. Sex differences of leukocytes DNA methylation adjusted for estimated cellularproportions. Biology of Sex Differences, 25;6:11, 2015.6 doi: 10.1186/s13293-015-0029-7.
  6. Shibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Wschek J, Koves K, Reglodi D, Tamas A, Matsuda T, Baba A, Hashimoto H. Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Neuroscience, 297:95-104, 2015.6 doi: 10.1016/j.neuroscience.2015.03.062.
  7. Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda K, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A. The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-like Behavior in Genomic Association Study. Curr Mol Med, 15(3):265-74, 2015.5 doi: 10.2174/1566524015666150330145722
  8. Higashi S, Katagi K, Shintani N, Ikeda K, Suimoto Y, Tsuchiya S, Inoue N Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimto H. p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice. Biochemical and Biophysical Research Communications, 461:612-617, 2015.4 doi: 10.1016/j.bbrc.2015.04.074
  9. Matuura Y, Fujino H, Hashimoto R, Yasuda Y, Yamamori H, Ohi K, Takeda T, Imura O. Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications. Gait & Posture, 41:847-851, 2015.4 (e-pub) doi: 10.1016/j.gaitpost.2015.03.006
  10. Ohi K, Ursini G, Li M, Shin J.H.,Ye T, Chen Q, Tao R, Kleinman JE., Hyde TM., Hashimoto R, Weinberger DR. DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain. Translational Psychiatry, 14;5:e550, 2015.4 doi: 10.1038/tp.2015.45.
  11. Ogata K, Shintani N, Hayata-Takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudry D, Vaudry H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H. PACAP enhances axon and neurite outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PloS One, 25;10(3):e0120526, 2015.3 doi: 10.1371/journal.pone.0120526.
  12. Matsuno H, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Yano-Umeda S, Saneyoshi T, Takeda M, Hayashi Y. A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PLoS One, 13;10(3):e0116319, 2015.3 doi: 10.1371/journal.pone.0116319.
  13. Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivieres S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala B, Armstrong NJ, Bernard M, Bohlken M, Boks MP, Bralten J, Brown AA, Chakravarty M, Chen Q, Ching C, Cuellar-Partida G, Den Braber A, Giddaluru S, Goldman AL, Grimm O, Guadalupe T,Hass J, Woldehawariat G, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kim S,Klein M, Kraemer B, Lee PH, Loohuis L.O., Luciano M, Macare C, Mather KA, Mattheisen M, Milaneschi Y, Nho K, Papmeyer M, Ramasamy A, Risacher SL, Roiz-Santianez R, Rose EJ, Salami A, Samann P, Schmaal L, Schork AJ, Shin J, Strike LT, Teumer A, Van Donkelaar MJ, Van Eijk K, Walters RK, Westlye LT, Whelan CD, Winkler AM, Zwiers MP, Alhusaini S, Athanasiu L, Ehrlich S, Hakobjan MH, Hartberg CB, Haukvik U, Heister A.H, Hohn D, Kasperaviciute D, Liewald D C.M, Lopez LM, Makkinje R, Matarin M, Naber M, McKay DR, Needham M, Nugent AC, Putz B, Royle NA, Shen L, Sprooten E, Trabzuni D, Van der Marel S, Van Hulzen K, Walton E, Wolf C, Almasy L, Ames D, Arepalli, Assareh A, Bastin M, Brodaty H, Bulayeva K, Carless M, Cichon S, Corvin A, Curran J, Czisch M, De Zubicaray G, Dillman A, Duggirala R, Dyer T, Erk S, Fedko IF, Ferrucci L, Foroud TM, Fox PP, Fukunaga M, Gibbs R, Goring H, Green R, Guelfi M, Hansell N, Hartman CA, Hegenscheid K, Heinz A, Hernandez DF, Hesenfeld DJ, Hoekstra PJ, Holsboer F, Homuth G, Hottenga JJ, Ikeda M, Jack Jr CR, Jenkinson M, Johnson R, Kanai R, Keil M, Kent Jr JW, Kochunov P, Kwok JB, Lawrie SM, Liu X, Longo D, McMahon K, Meisenzahl E, Melle I, Mohnke S, Montgomery G, Mostert J, Muhleisen T, Nalls M, Nichols TE, Nilsson LG, Nothen M, Ohi K, Olvera R, Perez-Iglesias R, Pike G.B., Potkin S, Reinvang I, Reppermund S, Rietschel M, Romanczuk-Seiferth N, Rosen G, Rujescu D, Schnell K, Schofield P, Smith C, Steen V, Sussmann J, Thalamuthu A, Toga A, Traynor B, Troncoso J, Turner J, Hernandez MC, Van 't Ent D, Van der Brug M, Van der Wee N, Van Tol M.J, Veltman D, Wassink T, Westman E, Zielke H, Zonderman A, Ashbrook D, Hager R, Lu L, McMahon F, Morris D, Williams R, Brunner H, Buckner R, Buitelaar J, Cahn W, Calhoun VD, Cavalleri G, Crespo-Facorro B, Dale A, Davies G, Delanty N, Depondt C, Djurovic S, Drevets W, Espeseth T, Gollub R, Ho BC, Hoffmann W, Hosten N, Kahn R, Le Hellard S.L., Meyer-Lindenberg A, Muller-Myhsok B, Nauck M, Nyberg L, Pandolfo M, Penninx B, Roffman J, Sisodiya S, Smoller J, Van Bokhoven H, Van Haren N, Volzke H, Walter H, Weiner M, Wen W, White T, Agartz I, Andreassen O, Blangero J, Boomsma D, Brouwer R, Cannon D, Cookson M, De Geus E, Deary I, Donohoe G, Fernandez G, Fisher S, Francks C, Glahn D, Grabe H, Gruber O, Hardy J, Hashimoto R, (292名中237番目) Hulshoff Pol H, Jonsson E, Kloszewska I, Lovestone S, Mattay V, Mecocci P, McDonald C, McIntosh A, Ophoff R, Pausova Z, Paus T, Ryten M, Sachdev P, Saykin A, Simmons A, Singleton A, Soininen H, Wardlaw J, Weale M, Weinberger DR, Adams H, Launer L, Seiler S, Schmidt R, Chauhan G, Satizabal C, Becker J, Yanek L, Van der Lee S, Ebling M, Fischl B, Longstreth W, Greve D, Schmidt H, Nyquist P, Vinke L, Van Duijn C, Luting X, Mazoyer B, Bis J, Gudnason V, Seshadri S, Ikram M, the ADNI, the CHARGE, the EPIGEN, the IMAGEN, the SYS, Martin N, Wright M, Schumann M, Franke B, Thompson P, Medland S.E.Common genetic variants influence human subcortical brain structures. Nature, 9;520(7546):224-9, 2015.4 doi: 10.1038/nature14101
  14. Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H. Simultaneous neuron- and astrocyte-specific fluorescent marking. Biochemical and Biophysical Research Communications, 459:81-86, 2015.3 doi: 10.1016/j.bbrc.2015.02.073.
  15. Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, matsuda T, Baba A, Hashimoto H. Identification of the role of BMP and TGF-β signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro. Journal of Neurochemistry, 132(4):418-28, 2015.2 doi: 10.1111/jnc.12999
  16. Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata K, Nakamura M, Hashimoto R, Matsuda T, Waschek J.A., Kasai A, Nagayasu K, Baba A, Hashimoto H. CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. Behavioural Brain Research, 284:131-137, 2015.2 doi:10.1016/j.bbr.2015.02.013
  17. Ikeda M, Yoshimura R, Hashimoto R, Kondo K, Saito T, Shimasaki A, Ohi K, Tochigi M, Kawamura Y, Nishida N, Miyagawa T, Sasaki T, Tokunaga K, Kasai K, Takeda M, Nakamura J, Ozaki N, Iwata N. Genetic overlap between antipsychotic response and susceptibility to schizophrenia. Journal of Clinical Psychopharmacology, 35(1):85-8, 2015.2 doi: 10.1097/JCP.0000000000000268.

2014年

  1. Miura K, *Hashimoto R, Fujimoto M, Yamamori H, Yasuda Y, Ohi K, Umeda-Yano S, Fukunaga M, Iwase M, Takeda M. An integrated eye movement score as a neurophysiological marker of schizophrenia. Schizophrenia Research, 160(1-3):228-9, 2014.12 doi: 10.1016/j.schres.2014.10.023.
  2. Li M, Ohi K, Chen C, He Q, Lu JW, Chen C. Luo XJ, Dong Q, Hashimoto R, Su B. Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from theEuropean genome-wide association study in Asian populations. Neurobiology of Aging, 35(12):2883e.1-2, 2014.12, doi: 10.1016/j.neurobiolaging.2014.07.015.
  3. Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Takeda M, Ohmori T. Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions. NeuroMolecular Medicine, 16:697-703, 2014. 12 doi 10.1007/s12017-014-8319-5
  4. Shintani N, Onaka Y, *Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H. Behavioral characterization of mice overexpressing human dysbindin-1. Molecular Brain, 9;7(1):74, 2014.10 doi:10.1186/s13041-014-0074-x
  5. *Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Ochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N. Common variants at 1p36 are associated with superior frontal gyrus volume. Translational Psychiatry, 4:e472, 2014. 10 doi:10.1038/tp.2014.110
  6. Miki K, Hashimoto R, Shi K, Yukioka M, Opioid therapy for knee osteoarthritis and postoperative persistent pain after knee arthroplasty. Rheumatology, 53(10):1723-4. 2014.10 doi:10.1093/rheumatology/keu309
  7. Iwata R, Ohi K, Kobayashi Y, Masuda A, Masuda A, Iwama M, Yasuda Y, Yamamori H, Tanaka M, Hashimoto R, Itohara S, Iwasato T. RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood. Cell Report, 8(5):1257-64, 2014.8 doi: 10.1016/j.celrep.2014.07.047.
  8. Yamamori H, *Hashimoto R, Fujita Y, Numata S, Yasuda Y, Fujimoto M, Ohi K, Umeda-Yano S, Ito A, Ohmori T, Hashimoto K, Takeda M. Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment. Neurosci Lett, 582:93-8, 2014.10 doi: 10.1016/j.neulet.2014.08.052.
  9. Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T. Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia, Schizophrenia Bulletin, 40(5):1154-63, 2014.9 doi: 10.1093/schbul/sbt154
  10. Yasuda Y, *Hashimoto R, Fukai R, Okamoto N, Hirai Y, Yamamori H, Fujimoto M, Ohi K, Taniike M, Mohri I, Nakashima M, Tsurusaki Y, Saitsu H, Matsumoto N, Miyake N, Takeda M. Duplication of the NPHP1 gene in patients with autism spectrum disorder and normal intellectual ability: a case series. Annals of General Psychiatry, 13:22. 2014.8 doi: 10.1186/s12991-014-0022-2.
  11. Watanabe Y, Tanaka H, Tsukabe A, Kunitomi Y, Nishizawa M, Hashimoto R, Yamamori H, Fujimoto M, Fukunaga M, Tomiyama N. Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia. PLos One, 11:9(8):e104619, 2014.8 doi: 10.1371/journal.pone.0104619
  12. Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, *Hashimoto R, Takeda M, Imura O. Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia. Psychiatry and Clinical Neurosciences, 68(7):534-541, 2014.7 doi: 10.1111/pcn.12165.
  13. Yasuda Y, *Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Takeda M. Cognitive inflexibility in Japanese adolescents and adults with autism spectrum disorders. Workd J Psychiatr, 22;4(2):42-48, 2014.6 doi: 10.5498/wjp.v4.i2.42
  14. Nishizawa D, Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Takeda M, Ikeda K. Association between genetic polymorphism rs2952768, close to the METTL21A and CREB1 genes, and intellectual ability in healthy subjects. Journal of Addiction Research & Therapy, 5(2):1000178, 2014.6 doi: 10.4172/2155-6105.1000178
  15. Ohi K, *Hashimoto R, Ikeda M, Yamashita F, Fukunaga M, Nemoto K, Ohnishi T, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Watanabe Y, Iwata N, Weinberger DR, Takeda M. Genetic risk variants of schizophrenia associated with left superior temporal gyrus volume. Cortex, 58C:23-26, 2014.6 doi: 10.1016/j.cortex.2014.05.011.
  16. Horiguchi M, Ohi K, *Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H. A functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects intelligence quotient in schizophrenia. Psychiatry and Clinical Neurosciences, 68(6):456-62, 2014.6 doi: 10.1111/pcn.12157.
  17. Dickinson D, Straub RE, Trampush JW, Gao Y, Feng N, Xie B, Shin JH, Lim HK, Ursini G, Bigos KL, Kolachana B, Hashimoto R, Takeda M, Baum GL, Rujescu D, Callicott JH, Hyde TM, Berman KF, Kleinman JE, Weinberger DR. Differential Effects of Common Variants in SCN2A on General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals. JAMA Psychiatry. 1;71(6):647-56, 2014.6 doi: 10.1001/jamapsychiatry.2014.157.
  18. Ohgidani M, Kato T.A., Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S. Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease. Scientific Reports 14;4:4957, 2014.5 doi: 10.1038/srep04957.
  19. Umeda-Yano S, *Hashimoto R, Yamamori H, Wickertd CS, Yasuda Y, Ohi K, Fujimoto M, Ito A, Takeda M. Expression analysis of the genes identified in GWAS of the postmortem brain tissues from patients with schizophrenia. Neurosci Lett, 568:12-16, 2014.3 doi: 10.1016/j.neulet.2014.03.031.
  20. Yasuda Y, *Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Horiguchi M, Takeda M, Ichinose H. A functional polymorphism of the GTP cyclohydrolase I gene predicts attention performance. Neurosci Lett, 566:46-49, 2014.3 doi: 10.1016/j.neulet.2014.02.019.
  21. Fukumoto M, *Hashimoto R, Ohi K, Yasuda Y, Yamamori H, Umeda-Yano S, Iwase M, Kazui H, Takeda M. Relation between remission status and attention in patients withn schizophrenia. Psychiatry and Clinical Neurosciences, 68(3):234-41, 2014.3 doi: 10.1111/pcn.12119
  22. Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silvermama M, Kimura N, Satoa M, Saito Y, Suzuki T, Yanagida K, Kodama T, Tanaka T, Okochi M, Tagami , Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Kabata-Yamagichi Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta accumulation modifier. Proc. Natl. Acad. Sci., 18;111(7):2638-43, 2014.2 doi: 10.1073/pnas.1307345111.
  23. Haba R, Shintani N, Onaka Y, Kanoh T, Wang H, Takenaga R, Hayata A, Hirai H, Nagata K, Nakamura M, Kasai A, Hashimoto R, Nagayasu K, Nakazawa T, Hashimoto H, Baba A. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. The Journal of Neuroscience, 12;34(7):2514-23, 2014.2 doi: 10.1523/JNEUROSCI.1407-13.2014.
  24. Hazama K, Hayata-Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, Nagayasu K, Hashimoto R, Reglodi D, Miyakawa T, Nakazawa T, Baba A, Hashimoto H. Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice. PLoS One, 20;9(2):e89153, 2014.2 doi: 10.1371/journal.pone.0089153
  25. Miyashita M, Arai M, Yuzawa H, Ichikawa T, Nohara I, Arai M, Obata N, Toriumi K, Kobori A, Niizato K, Ooshima K, Kushima I, Hashimoto R, Fukumoto M, Koike S, Toyota T, Ujike H, Arinami T, Kasai K, Takeda M, Ozaki N, Okazaki Y, Yoshikawa T, Amano N, Miyata T, Itokawa M. Replication of enhanced carbonyl stress in a subpopulation of schizophrenia. Psychiatry and Clinical Neurosciences, 68(1):83-4, 2014.1 doi: 10.1111/pcn.12081.
  26. Nakai K, Nakae A, Hashimoto R, Mashimo T, Hosokawa K. Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. J Oral Facial Pain Headache. 2014 Winter;28(1):61-7.2014.1 doi: 10.11607/jop.1105.
  27. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T. Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int J Neuropsychopharmacol, 17:443-453, 2014.1 doi: 10.1017/S1461145713001302

2013年

  1. Watanabe Y, Iijima Y, Egawa J, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Sasaki T, Ozaki N, Hashimoto R, Shibuya M, Igeta H, Someya T. Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia. Schizophr Res, 150(2-3):596-7, 2013.11 doi: 10.1016/j.schres.2013.08.028.
  2. Yamamori H, *Hashimoto R, Ishima T, Kishi F, Yasuda Y, Ohi K, Fujimoto M, Umeda-Yano S, Ito A, Hashimoto K, Takeda M. Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine. Neurosci Lett, 556(2013):37-41, 2013.11 doi: 10.1016/j.neulet.2013.09.059.
  3. Kitaichi Y, *Hashimoto R, Inoue T, Abekawa T, Kakuta A, Hattori S, Koyama T. Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice. Acta Neuropsychiatrica, 4:215-20, 2013. 10 doi: 10.1111/acn.12018.
  4. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Fujimoto M, Iwase M, Kazui H, Takeda M. Influence of the NRGN gene on intellectual ability in schizophrenia. Journal of Human Genetics, 58(10):700-5, 2013.10 doi: 10.1038/jhg.2013.82.
  5. Kanazawa T, Ikeda M, Glatt S.J, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H. Genome-Wide Association Study of Atypical Psychosis. Am J Med Genet B Neuropsychiatry Genet, 162(7):679-86, 2013.10 doi: 10.1002/ajmg.b.32164.
  6. Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Watanabe Y, Iwase M, Kazui H, Takeda M. The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia. Behavioral and Brain Functions, 9(1):40, 2013.10 doi: 10.1186/1744-9081-9-40.
  7. Seo S, Takayama K, Uno K, Ohi K, Hashimoto R, Nishizawa D, Ikeda K, Miyamoto y, Ozaki N, Nabeshima T, Nitta A. Functional analysis of deep intronic SNP rs13438494 in intron 24 of PCLO gene. PLoS One, 8(10): e76960, 2013.10 doi: 10.1371/journal.pone.0076960.
  8. Ohi K, *Hashimoto R, Yamamori H, Yasuda Y, Fujimoto M, Nakatani N, Kamino K, Takeda M. How to diagnose the 22q11.2 deletion syndrome in patients with schizophrenia: a case report. Annals of General Psychiatry, 12(1):29, 2013.9 doi: 10.1186/1744-859X-12-29
  9. Ikeda M, Okahisa Y, Aleksic B, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Sora I, Iyo M, Hashimoto R, Kawamura Y, Ninishida N, Miiyagawa T, Takeda M, Sasaki T, Tokunaga K, Ozaki N, Ujike H, Iwata N. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. Neuropsychopharmacology, 38(10):1864-70, 2013.9 doi: 10.1038/npp.2013.94.
  10. Furukawa M, Tochigi M, Otowa T, Arinami T, Inada T, Ujike H, Watanabe Y, Iwata N , Itokawa M, Kunugi H, Hashimoto R, Ozaki N, Kakiuchi C, Kasai K, Sasaki T, An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population. Psychiatr Genet, 23(4):179-180, 2013.8 doi: 10.1097/YPG.0b013e328360c8be.
  11. *Hashimoto R, Ikeda M, Ohi K, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M. Genome-wide association study of cognitive decline in schizophrenia. Am J Psychiatry, 170(6):683-684, 2013.6 doi: 10.1176/appi.ajp.2013.12091228.
  12. Manchia M, Adli M, Akula N, Ardau R, Aubry J.M., Backlund L, Banzato C, Baune B, Bellivier F, Bengeser S, Biernacka J, Brichant-Petitjean C, Bui E, Calkin C, Cheng A, Chillotti C, Cichon S, Clark S, Czerski P, Dantas C, Zompo M, DePaulo J, Detera-Wadleigh S, Etain B, Falkai P, Frisen L, Frye M, Fullerton J, Gard S, Garnham J, Goes F, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hobann R, Hou L, Jamain S, Kahn J, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Kuo P, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband S, Jaaramillo C, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell P, Mondimore F, Monteleone P, Nallet A, Neuner M, Novak T, O'Donovan C, Osby U, Ozaki N, Perlis R, Pfennig A, Potash J, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau G, Rybakowski J, Schalling M, Schofield P, Schubert O, Schweizer B, Seemuller F, Grigoroiu-Serbanescu M, Severino G, Seymour L, Slaney C, Smoller J, Squassina A, Stamm T, Steele J, Stopkova P, Tighe S, Tortorella A, Turecki G, Wray N, Wright A, Zandi P, Zilles D, Bauer M, Rietschel M, McMahon F, Schulze T, Alda M. Assessment of Response to Lithium maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report, PLoS One, 8(6): e65636, 2013.6 DOI: 10.1371/journal.pone.0065636
  13. Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. Schizophrenia Bulletin. 39(3):720-8, 2013.5 doi: 10.1093/schbul/sbs038
  14. Umeda-Yano S, *Hashimoto R, Yamamori H, Okada T, Yasuda Y, Ohi K, Fukumoto M, Ito A, Takeda M. The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia. Schizophr Res, 146(1-3):273-8, 2013.5 doi: 10.1093/schbul/sbs038
  15. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M. The AKT1 gene is associated with attention and brain morphology in schizophrenia. World J Biol Psychiatry. 14(2):100-13, 2013.3 doi: 10.3109/15622975.2011.591826.
  16. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M. The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. World J Biol Psychiatry. 14(2):114-20, 2013.3 doi: 10.3109/15622975.2011.604350.

2012年

  1. Ota M, Sato N, Ishikawa M, Hori H, Sasayama D, Hattori K, Teraishi T, Obu S, Nakata Y, Nemoto K, Moriguchi Y, Hashimoto R, Kunugi H. Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry. Psychiatry and Clinical Neurosciences, 66(7):611-7, 2012.12 doi: 10.1111/j.1440-1819.2012.02397.x.
  2. Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Itakura M, Takeda M, Ohmori T. Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population. Schizophr Res, 141(2-3):271-3, 2012.11 doi: 10.1016/j.schres.2012.07.020.
  3. Okada T, *Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A, Takeda M. Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A. Schizophr Res, 141(2-3):277-8, 2012.11 doi: 10.1016/j.schres.2012.08.015.
  4. Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No Associations Found between the Genes Situated at 6p22.1, HIST1H2BJ, PRSS16 and PGBD1 in Japanese Patients Diagnosed With Schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(4): 456-64, 2012.6 doi: 10.1002/ajmg.b.32049.
  5. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M. Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. Psychiatry Research, 198(1):7-11, 2012.6 doi: 10.1016/j.psychres.2011.12.018.
  6. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M. Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(4):405-13, 2012.6 doi: 10.1002/ajmg.b.32043.
  7. Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D. Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. Schizophr Res, 137(1-3):246-50, 2012.5 doi: 10.1016/j.schres.2012.01.031.
  8. Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa Ma, Ozaki N, Hashimoto R, Someya T. A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population. Schizophrenia Research, 137:264-266, 2012.5 doi: 10.1016/j.schres.2012.01.034.
  9. Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujiike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N. Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients. PLos One, 7(5):e36836, 2012.5 doi: 10.1371/journal.pone.0036836.
  10. Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N. Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility. Schizophr Bull, 38(3):552-560, 2012.5 doi: 10.1093/schbul/sbq118.
  11. Ohi K, *Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M. The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits. PLoS One, 7(4):e35696, 2012.4 doi: 10.1371/journal.pone.0035696.
  12. Yamamori H, *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M. A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait. Neurosci Lett, 513(3):204-208, 2012.2 doi: 10.1016/j.neulet.2012.02.039.
  13. Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M. Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects. Neuroscience Research 72(2):187-193, 2012.2 doi: 10.1016/j.neures.2011.10.009.
  14. Ohi K, *Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M. Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia. PLoS One, 7(1):e29780, 2012.1 doi: 10.1371/journal.pone.0029780.

2011年

  1. Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, Sato N, Iwata N, Kunugi H. A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes. Prog Neuropsychopharmacol Biol Psychiatry. 35(8):1877-1883, 2011.12 doi: 10.1016/j.pnpbp.2011.07.012.
  2. Takahashi H, Hashimoto R, Iwase M, Ishii R, Kamino Y, Takeda M. Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease. Clinical Psychopharmacology and Neuroscience. 9(3):102-110, 2011.12
  3. Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto M, Yasuda Y, Iike N, Takaya M, Yamamori H, Kazui H, Hashimoto R, Yoshimine T, Takeda M. Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia: A magnetoencephalography-beamformer study. Neurosci Res. 71(3):235-43, 2011.11 doi: 10.1016/j.neures.2011.07.1819.
  4. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology, 36(9):1921-1931, 2011.8 doi: 10.1038/npp.2011.78.
  5. Yamamori H, *Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M. Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia, J Hum Genet, 56(7):478-83, 2011.7 doi: 10.1038/jhg.2011.40.
  6. Yasuda Y, *Hashimoto R, Yamamori H, Ohi K, Fukumoto M, Umeda-Yano S, Mohri I, Ito A, Taniike M, Takeda M. Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder. Molecular Autism, 2(1):9, 2011.5 doi: 10.1186/2040-2392-2-9.
  7. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M. No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. Schizophrenia Res, 129:80-84, 2011.6 doi: 10.1016/j.schres.2011.03.024.
  8. Yasuda Y, *Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M. Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene. Neurosci let, 495:216-220, 2011.5 doi: 10.1016/j.neulet.2011.03.069.
  9. Ohi K, *Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M. The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry, 35:1309-1315, 2011.4 doi: 10.1016/j.pnpbp.2011.04.008.
  10. Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A. PACAP is Implicated in the Stress Axes, Curr Pharm Des, review, 17(10):985-9, 2011.4 10.2174/138161211795589382
  11. Kobayashi K, Umeda-Yano S, Yamamori H, Takeda M, Suzuki H, Hashimoto R. Correlated Alterations in Serotonergic and Dopaminergic Modulations at the Hippocampal Mossy Fiber Synapse in Mice Lacking Dysbindin. PLoS One, 23;6(3):e18113, 2011.3 doi: 10.1371/journal.pone.0018113
  12. Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan MC, Iwata N. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biol Psychiatry, 69(5):472-478, 2011.3. doi: 10.1016/j.biopsych.2010.07.010.
  13. Cacabelos R, Hashimoto R, Takeda M. Pharmacogenomics of antipsychotics efficacy for schizophrenia. Psychiatry Clin Neurosci. 65(1):3-19, 2011.2 doi: 10.1111/j.1440-1819.2010.02168.x.
  14. Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M. Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer’s Disease in the Mild Cognitive Impairment Stage. Dement Geriatr Cogn Disord. 2011:1:20-30, 2011.1 doi: 10.1159/000323561
  15. Nihonmatsu-Kikuchi N, Hashimoto R, Hattori S, Matsuzaki S, Shinozaki T, Miura H, Ohota S, Tohyama M, Takeda M, Tatebayashi Y. Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse. PLoS One, 18;6(1):e15886, 2011.1 doi: 10.1371/journal.pone.0015886.

2010年

  1. *Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M. The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia. Am J Med Genet B Neuropsychiatry Genet, 153B(8):1459-1464, 2010.12 doi: 10.1002/ajmg.b.31123.
  2. Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R. Apolipoprotein E and central nervous system disorders: reviews of clinical findings. Psychiatry Clin Neurosci. 64(6):592-607, 2010.12 doi: 10.1111/j.1440-1819.2010.02148.x.
  3. Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Mol Brain.3(1):37, 2010.11. doi: 10.1186/1756-6606-3-37.
  4. Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M. KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. Dement Geriatr Cogn Disord. 30(4):302-308, 2010.10. doi: 10.1159/000320482.
  5. Yasuda Y, *Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M. Association study of KIBRA gene with memory performance in a Japanese population. World J Biol Psychiatry, 11(7):852-857.2010.10 doi: 10.3109/15622971003797258.
  6. Numata S, Nakataki M, Iga J, Tanahashi T, Nakadoi Y, Ohi K, Hashimoto R, Takeda M, Itakura M, Ueno S, Ohmori T. Association study between the pericentrin (PCNT) gene and schizophrenia. Neuromolecular Med, 12(3):243-247. 2010.9 doi: 10.1007/s12017-009-8106-x.
  7. Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M. Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. Psychophysiology, 47(5):831-837. 2010.9 doi: 10.1111/j.1469-8986.2010.01000.x.
  8. Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama T, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M. The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. Psychogeriatrics, 10(3):117-123, 2010.9 doi: 10.1111/j.1479-8301.2010.00330.x.
  9. Takebayashi M, Hashimoto R, Hisaoka K, Tsuchioka M, Kunugi H. Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders. J Neural Transm. 117(9):1119-1122. 2010.9 doi: 10.1007/s00702-010-0452-1.
  10. Koide T, Aleksic B, Ito Y, Usui H, Yoshimi A, Inada T, Suzuki M, Hashimoto R, Takeda M, Iwata N, Ozaki N. A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet. 55(7):469-472. 2010.7 doi: 10.1038/jhg.2010.38.
  11. Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T. Laughter and humor as complementary and alternative medicines to dementia patients. BMC Complement Altern Med, 10(1):28, 2010.6 doi: 10.1186/1472-6882-10-28.
  12. Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T. Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study. Schizophr Res, 118(1-3):106-112, 2010.5 doi: 10.1016/j.schres.2010.01.023.
  13. Ohnuma T, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Okochi T, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H. No association between DAO and schizophrenia in a Japanese patient population: A multicenter replication study. Schizophr Res, 118(1-3):300-302, 2010.5 doi: 10.1016/j.schres.2010.01.028.
  14. Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y. A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome. Life Sci, 86(19-20):722-725, 2010.5 doi: 10.1016/j.lfs.2010.03.007.
  15. Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N. Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population. Schizophr Res, 118(1-3):113-117, 2010.5 doi: 10.1016/j.schres.2010.01.014.
  16. Schulze T, Alda M, Adli M, Akula N, Ardau R, Chillotti C, Cichon S, Czerski P, Zompo M, SDetera-Wadleigh S, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe J, Kusumi I, Laje G, Leckband S, Manchia M, MacQueen G, Masui T, Ozaki N, Perlis R, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski J, Sasse J, Schumacher J, Severino G, Smoller J, Squassina A, Turecki G, Young T, Yoshikawa T, Bauer M, McMahon F. The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment, Neuropsychobiology, 62(1):72-78, 2010.5 doi: 10.1159/000314708.
  17. Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H. Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res, 67:181-191, 2010.4 doi: 10.1016/j.neures.2010.03.004.
  18. Azechi M, Iwase M, Ikezawa K, Takahashi H, Canuet L, Kurimoto R, Nakahachi T, Ishii R, Fukumoto M, Ohi K, Yasuda Y, Kazui H, Hashimoto R, Takeda M. Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: A near-infrared spectroscopy. Schizophr Res, 117(1):52-60, 2010.3 doi: 10.1016/j.schres.2009.10.003.
  19. *Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry 11:431-438. 2010.3 doi: 10.1080/15622970902736503.
  20. Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams H, Takeda M, Nakamura J, Nabeshima T, Owen M, O'Donovan M, Honda H, Arinami T, Ozaki N, Iwata N. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression and genetic case-control association approaches. Biol Psychiatry, 67(3):263-269, 2010.2 doi: 10.1016/j.biopsych.2009.08.030.
  21. Ohi K, *Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M. The Chitinase 3-Like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. Schizophr Res, 116:126-132, 2010.2 doi: 10.1016/j.schres.2009.12.002
  22. *Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neurosci Lett, 468(3):300-302, 2010.1 doi: 10.1016/j.neulet.2009.11.019.

2009年

  1. Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Nakahachi T, Hashimoto R, Takeda M. Working memory abnormalities in chronic interictal epileptic psychosis and schizophrenia revealed by magnetoencephalography. Epilepsy Behav. 17(1):109-119, 2010.1 doi: 10.1016/j.yebeh.2009.11.002.
  2. Okuda H, Kuwahara R, Matsuzaki S, Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M. Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. PLoS One, 5(1):e8773, 2010.1 doi: 10.1371/journal.pone.0008773.
  3. Nunokawa A, Watanabe Y, Kaneko N, Sugai T, Yazaki S, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Itokawa M, Ozaki N, Hashimoto R, Someya T. The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis. Schizophr Res, 116(1):61-67, 2010.1 doi: 10.1016/j.schres.2009.10.016.
  4. Moriwaki M, Kishi T, Takahashi H, Hashimoto R, Kawashima K, Okochi T, Furukawa O, Fujita K, Takeda M, Iwata N. Prepulse inhibition of the startle response with chronic schizophrenia: A replication study. Neurosci Res, 65(3):259-262, 2009.11 doi: 10.1016/j.neures.2009.07.009.
  5. *Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H. Association analysis between schizophrenia and the AP-3 complex genes. Neurosci Res, 65(1):113-115, 2009.9 doi: 10.1016/j.neures.2009.05.008.
  6. Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K. Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein. J Neurochem, 110(5):1567-1574, 2009.9 doi: 10.1016/j.neures.2009.05.008
  7. Ohi K, *Hashimoto R, Yasuda Y, Yamamori H, Hori H, Saitoh O, Tatsumi M, Takeda M, Iwata N, Ozaki N, Kamijima K, Kunugi H. No association between the Bcl2-interacting killer (BIK) gene and schizophrenia. Neurosci Lett, 463(1):60-63, 2009.9 doi: 10.1016/j.neulet.2009.07.063.
  8. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci 63(4):550-556, 2009.8 doi: 10.1111/j.1440-1819.2009.01985.x.
  9. Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. J Neurochem, 110(2):595-602, 2009.7 doi: 10.1111/j.1471-4159.2009.06168.x
  10. Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda K, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, kiyama H, Kuwano R, Takeda M. The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system. EMBO Mol Med, 1:223-235, 2009.7 doi: 10.1002/emmm.200900026.
  11. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M. Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem, 110(2):496-508, 2009.7 doi: 10.1111/j.1471-4159.2009.06099.x.
  12. Ohi K, *Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res, 109(1-3), 80-85, 2009.4doi: 10.1016/j.schres.2009.01.019.
  13. Ikezawa K, Iwase M, Ishii R, Azechi M, Canuet L, Ohi K, Yasuda Y, Iike N, Kurimoto R, Takahashi H, Nakahachi T, Sekiyama R, Yoshida T, Kazui H, Hashimoto R, Takeda M. Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: a two-channel near-infrared spectroscopy study. Schizophr Res 108(1-3):93-103, 2009.3 doi: 10.1016/j.schres.2008.12.010.
  14. Kubota K, Kumamoto N, Matsuzaki S, Hashimoto R, Hattori T, Okuda H, Takamura H, Takeda M, Katayama T, Tohyama M. Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization. Biochem Biophys Res Commun, 379(2), 191-195, 2009.2 doi: 10.1016/j.bbrc.2008.12.017.
  15. *Hashimoto R, Hirata Y, Asada T, Yamashita F, Nemoto K, Mori T, Moriguchi Y, Kunugi H, Arima K, Ohnishi T. Effect of the BDNF and the ApoE polymorphisms on disease progression in preclinical Alzheimer's disease. Genes Brain Behav, 8(1), 43-52, 2009.2 doi: 10.1111/j.1601-183X.2008.00440.x.
  16. Ohi K, *Hashimoto R, Yasuda Y, Kiribayashi M, Iike N, Yoshida T, Azechi M, Ikezawa K, Takahashi H, Morihara T, Ishi R, Tagami S, Iwase M, Okochi M, Kamino K, Kazui H, Tanaka T, Kudo T, Takeda M. TATA Box-Binding Protein gene is associated with risk for schizophrenia, age at onset and prefrontal function. Genes Brain Behav, 8(4):473-480, 2009.1 doi: 10.1111/j.1601-183X.2009.00497.x.
  17. *Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Kunugi H, Saitoh O, Ohnishi T. Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging. World J Biol Psychiatry, 10(1): 65-69, 2009.1 doi: 10.1080/15622970701762536.

2008年

  1. Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Yoshida T, Yasuda Y, Hashimoto R, Takeda M. Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia. Neurosci Res, 62(3), 187-197, 2008.11 doi: 10.1016/j.neures.2008.08.006
  2. Ohi K, *Hashimoto R, Sugai F, Yasuda Y, Tagami S, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda S, Takeda M. Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms. Psychiatry Clin Neurosci, 62(5), 625, 2008. 10 doi: 10.1111/j.1440-1819.2008.01860.x.
  3. Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M, Miyakawa T, Hashimoto R. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain, 1(1):11, 2008.10 doi: 10.1186/1756-6606-1-11.
  4. Kawashima K, Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Takahashi N, Saito S, Ohi K, Yasuda Y, Hashimoto R, Takeda M, Inada T, Ozaki N, Iwata N. No Association between Tagging SNPs of SNARE Complex Genes (STX1A, VAMP2 and SNAP25) and Schizophrenia in a Japanese Population. Am J Med Genet. 147B(7):1327-1331, 2008.10 doi: 10.1002/ajmg.b.30781.
  5. Mizuguchi T, Hashimoto R, Itokawa M, Sano A, Shimokawa O, Yoshimura Y, Harada N, Miyake N, Nishimura A, Saitsu H, Sosonkina N, Niikawa N, Kunugi H, Matsumoto N. Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia. J Hum Genet, 53(10):914-919, 2008.8 doi: 10.1007/s10038-008-0327-6.
  6. Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H, *Hashimoto R. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Commun, 373(2):298-302, 2008.8 doi: 10.1016/j.bbrc.2008.06.016.
  7. *Hashimoto R, Moriguchi Y, Yamashita F, Mori T, Nemoto K, Okada T, Hori H, Noguchi H, Kunugi H, Ohnishi T. Dose Dependent Effect of the Val66Met Polymorphism of the Brain-Derived Neurotrophic Factor Gene on Memory-Related Hippocampal Activity. Neuroscience Res, 61(4):360-367, 2008.8 doi: 10.1016/j.neures.2008.04.003.
  8. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H. Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI), Psychiatry Res, 160(2):175-183, 2008.8 doi: 10.1016/j.psychres.2007.05.015
  9. Midorikawa A, Hashimoto R, Noguchi H, Saitoh O, Kunugi H, Nakamura K. Impairment of motor dexterity in schizophrenia assessed by a novel finger-movement test, Psychiatry Res, 159:281-289, 2008.6 doi: 10.1016/j.psychres.2007.04.004.
  10. Numata S, Shu-ichi Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T. TGFBR2 Gene expression and genetic association with schizophrenia. J Psychiatr Res, 42(6):425-432, 2008.5 doi.org/10.1016/j.jpsychires.2007.04.002
  11. Ikeda M, Takahashi N, Saito S, Aleksic B, Watanabe Y, Nunokawa A, Yamanouchi Y, Kitajima T, Kinoshita Y, Kishi T, Kawashima K, Hashimoto R, Ujike H, Inada T, Someya T, Takeda M, Ozaki N, Iwata N. Failure to replicate the association between NRG1 and schizophrenia using Japanese large-sample. Schizophr Res, 101:1-8, 2008.4 doi: 10.1016/j.schres.2008.01.010.
  12. Hori H, Noguchi H, Hashimoto R, Saitoh O, Okabe S, Kunugi H. IQ decline and memory impairment in Japanese patients with chronic schizophrenia, Psychiatry Res, 158:251-255, 2008.3 doi: 10.1016/j.psychres.2007.11.002.
  13. Numata S, Ueno S, Iga J, Nakataki M, Tanahashi T, Itakura M, Sano A, Ohi K, Hashimoto R, Takeda M, Ohmori T. No association between the NDE1 gene and schizophrenia in the Japanese Population. Schizophr Res, 99(1-3):367-369, 2008.2 doi: 10.1016/j.schres.2007.10.032.
  14. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Takeda M, Kunugi H, Koyama T. A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder, Prog Neuropsychopharmacol Biol Psychiatry, 32:204-208, 2008.1 doi.org/10.1016/j.pnpbp.2007.08.010
  15. Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda JI, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M. Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. J Hum Genet, 53(4):296-302, 2008.1 doi: 10.1007/s10038-008-0251-9.
  16. Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M. Regulation of notch signaling by dynamic changes in the precision of s3 cleavage of notch-1, Mol Cell Biol, 28(1):165-176, 2008.1 doi: 10.1128/MCB.00863-07

2007年

  1. *Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia, Mol Psychiatry, 12:1026-1032, 2007.12 doi:10.1038/sj.mp.4001982
  2. *Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects, Neurosci lett, 428(1):17-20, 2007.11 doi.org/10.1016/j.neulet.2007.09.036
  3. Kunugi H, Tanaka M, Hori H, Hashimoto R, Saitoh O, Hironaka N. Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia, Neuroscience Res, 59(1):23-28, 2007.9 doi.org/10.1016/j.neures.2007.05.006
  4. Hashimoto R, Tankou S, Takeda M, Sawa A. Postsynaptic density: A key convergent site for schizophrenia susceptibility factors and possible target for drug development. Drugs Today (Barc). 43(9):645-654, 2007.9 DOI: 10.1358/dot.2007.43.9.1088821
  5. Murotani T, Ishizuka T, Hattori S, Hashimoto R, Matsuzaki S, Yamatodani A. High dopamine turnover in the brains of Sandy mice. Neurosci Lett. 421(1):47-51, 2007.6 doi.org/10.1016/j.neulet.2007.05.019
  6. Hattori S, *Hashimoto R, Miyakawa T, Yamanaka H, Maeno H, Wada K, Kunugi H. Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi, Behavioural Brain Res, 180(1):69-76, 2007.6 doi.org/10.1016/j.bbr.2007.02.036
  7. Mori T, Ohnishi T, Hashimoto R, Nemoto K, Moriguchi Y, Noguchi H, Nakabayashi T, Hori H, Harada S, Saitoh O, Matsuda H, Kunugi H. Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging, Psychiatry Res: Neuroimaging, 154(2):133-145, 2007.2 doi.org/10.1016/j.pscychresns.2006.09.004
  8. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, Takeda M, Kunugi H, Itakura M, Ohmori T. Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia, Neurosci Lett, 415:28-33, 2007.1 doi.org/10.1016/j.neulet.2007.01.018
  9. Hong K, Sugawara Y, Hasegawa H, Hayasaka I, Hashimoto R, Ito S, Inoue-Murayama M. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats, Neurosci Lett, 412:195-200, 2007.2 doi.org/10.1016/j.neulet.2006.11.010
  10. Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between {beta}-amyloid production and tau phosphorylation in Alzheimer disease. Hum Mol Genet, 16:15-23, 2007.1 doi: 10.1093/hmg/ddl437

2006年

  1. *Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling. Hum Mol Genet, 15:3024-3033, 2006.10 doi: 10.1093/hmg/ddl244
  2. Kunugi H, Hashimoto R, Okada T, Hori H, Nakabayashi T, Baba A, Kudo K, Ohmori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Kosuga A, Tatsumi M, Kamijima K, Asada T, Harada S, Arima K, Saitoh O. Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population. J Neural Transm, 113:1569-1573, 2006.10 10.1007/s00702-006-0436-3
  3. Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H. Antipsychotic medication and cognitive function in schizophrenia. Schizophr Res, 86:138-146, 2006.9 doi.org/10.1016/j.schres.2006.05.004
  4. Chiba S, *Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger DR, Kunugi H. Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm, 113:1337-1346, 2006.9 10.1007/s00702-005-0414-1
  5. Okada T, Hashimoto R, Numakawa T, Iijima Y, Kosuga A, Tatsumi M, Kamijima K, Kato T, Kunugi H. A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity. Mol Psychiatry, 11:695-703, 2006.7 doi:10.1038/sj.mp.4001822
  6. Tanaka K, Shintani N, Hashimoto H, Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. J Neurosci. 26(19):5091-5097, 2006.5 doi: 10.1523/JNEUROSCI.4376-05.2006
  7. Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A, 103(17):6747-6752, 2006.4 doi: 10.1073/pnas.0602002103
  8. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Suzuki T, Iwata N, Ozaki N, Kato T, Kunugi H, Koyama T. Lithium response and Val66Met polymorphism of the BDNF gene in Japanese patients with bipolar disorder. Psychiatr Genet, 16(2):49-50, 2006.4 doi: 10.1097/01.ypg.0000180680.72922.57
  9. Nemoto K, Ohnishi T, Mori T, Moriguchi Y, Hashimoto R, Asada T, Kunugi H. The Val66Met polymorphism of the BDNF gene affects age-related brain morphology. Neurosci Lett 397(1-2):25-29, 2006.4 doi.org/10.1016/j.neulet.2005.11.067
  10. Ohnishi T, Hashimoto R, Mori T, Nemoto K, Moriguchi Y, Iida H, Yamada M, Noguchi H, Nakabayashi T, Hori H, Ohmori M, Tsukue R, Anami K, Hirabayashi N, Harada S, Arima K, Saitoh O, Kunugi H. The association between the Val158Met polymorphism of the Catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain, 129:399-410, 2006.2 doi: 10.1093/brain/awh702
  11. Masui T, *Hashimoto R, Kusumi I, Suzuki K, Tanaka T, Nakagawa S, Kunugi H, Koyama T. A possible association between -116C/G single nucleotide polymorphism of XBP1 gene and lithium prophylaxis in bipolar disorder. Int J Neuropsychopharmacol, 9(1):83-88, 2006.2 DOI: http://dx.doi.org/10.1017/S1461145705005523
  12. Kumamoto N, Matsuzaki S, Inoue K, Hattori T, Shimizu S, Hashimoto R, Yamatodani A, Katayama T, Tohyama M. Hyperactivation of Midbrain Dopaminergic System in Schizophrenia could be attributed to the Down-regulation of Dysbindin. Biochem Biophys Res Commun, 345:904-909, 2006.1 doi.org/10.1016/j.bbrc.2006.04.163

2005年以前

  1. Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekiyama R, Ukai S, Ishii, R, Ishigami W, Kajimoto O, Yamashita K, Hashimoto R, Shimizu A, Takeda M. Discrepancy of performance among working memory related tasks in autism spectrum disorders was caused by task characteristics apart from working memory which could interfere with task execution. Psychiatry Clin Neurosci, 60:312-318, 2006.1 DOI: 10.1111/j.1440-1819.2006.01507.x
  2. Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T. Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI. Neurosci Lett, 391(1-2):7-10, 2005.12 doi.org/10.1016/j.neulet.2005.08.023
  3. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y. Japanese Schizophrenia Sib-Pair Linkage Group. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility Loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet, 77(6):937-944, 2005.12 doi.org/10.1086/498122
  4. Tadokoro K, Hashimoto R, Tatsumi M, Kosuga A, Kamijima K, Kunugi H. The Gem interacting protein (GMIP) gene is associated with major depressive disorder. Neurogenetics, 6(3):127-133, 2005.9 10.1007/s10048-005-0003-3
  5. *Hashimoto R, Okada T, Kato T, Kosuga A, Tatsumi M, Kamijima K, Kunugi H. The breakpoint cluster region (BCR) gene on chromosome 22q11 is associated with bipolar disorder. Biol Psychiatry, 57(10):1097-1102, 2005.5 doi.org/10.1016/j.biopsych.2005.02.019
  6. Miki R, Hattori K, Taguchi Y, Tada M, Isosaka T, Hidaka Y, Hirabayashi T, Hashimoto R, Fukuzako H, Yagi T. Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-alpha and beta gene clusters. Gene, 349:1-14, 2005.4 doi.org/10.1016/j.gene.2004.11.044
  7. *Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men. Schizophr Res, 73(2-3):383-385, 2005.3 doi.org/10.1016/j.schres.2004.01.017
  8. *Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H. Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders. J Neural Transm, 112(2):303-307, 2005.3
  9. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, *Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet, 13(21):2699-2708, 2004.11 10.1007/s00702-004-0264-2
  10. Kusumi I, Masui T, Kakiuchi C, Suzuki K, Akimoto T, Hashimoto R, Kunugi H, Kato T, Koyama T. Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects. Neurosci Lett. 369(1):1-3, 2004.10 doi.org/10.1016/j.neulet.2004.07.003
  11. Numakawa T, Ishimoto T, Suzuki S, Numakawa Y, Adachi N, Matsumoto T, Yokomaku D, Koshimizu H, Fujimori KE, *Hashimoto R, Taguchi T, Kunugi H. Neuronal roles of integrin-associated protein (IAP/ CD47) in developing cortical neurons. J Biol Chem, 279(41):43245-43253, 2004.10 doi: 10.1074/jbc.M406733200
  12. Tadokoro K, Hashimoto R, Tatsumi M, Kamijima K, Kunugi H. Analysis on enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. Neuropsychobiology, 50(3):206-210, 2004.9 DOI:10.1159/000079971
  13. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in Japanese: a multi-center study. Biol Psychiatry, 56(5):376-378, 2004.9 doi.org/10.1016/j.biopsych.2004.06.017
  14. Kunugi H, Hashimoto R, Yoshida M, Tatsumi M, Kamijima K. A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. Am J Med Genet, 129B:44-46, 2004.8 DOI: 10.1002/ajmg.b.30062
  15. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR, Kleinman JE. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry, 61:544-555, 2004.6 doi:10.1001/archpsyc.61.6.544.
  16. Hashimoto R, Straub RE, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR. Expression Analysis of Neuregulin-1 in the Dorsolateral Prefrontal Cortex in Schizophrenia. Mol Psychiatry, 9(3):299-307, 2004.3 doi:10.1038/sj.mp.4001434
  17. *Hashimoto R, Yoshida M, Ozaki N, Yamanouchi Y, Iwata N, Suzuki T, Kitajima T, Tatsumi M, Kamijima K, Kunugi H. Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia. J Neural Transm, 111(2):217-221, 2004.2 10.1007/s00702-003-0101-z
  18. Jeong MR, Hashimoto R, Senatorov VV, Fujimaki K, Ren M, Lee MS, Chuang D-M. Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition. FEBS Lett, 542(1-3):74-78, 2003.5 doi.org/10.1016/S0014-5793(03)00350-8
  19. Matsumoto N, Nakamura Y, Kashiwagi Y, Hashimoto R, Kudo T, Tanaka T, Shinosaki K,Takeda M. Involvement of Rho-associated kinase in neurite sprouting and amyloid beta production of rat cortical neurons cultured in insulin-free medium. Psychogeriatrics, 3(1):21-28, 2003.5
  20. Hashimoto R, Senatorov V, Kanai H, Leeds P, Chuang D-M. Lithium Stimulates Progenitor Proliferation in Cultured Brain Neurons. Neuroscience, 117(1):55-61, 2003.3 doi.org/10.1016/S0306-4522(02)00577-8
  21. Hashimoto R, Fujimaki K, Jeong MR, Christ L, Chuang D-M. Lithium-induced Inhibition of Src Tyrosine Kinase in Rat Cerebral Cortical Neurons: A Role in Neuroprotection against N-methyl-D-aspartate Receptor-mediated Excitotoxicity. FEBS Lett, 538(1-3):145-148, 2003.3 doi.org/10.1016/S0014-5793(03)00167-4
  22. Hashimoto R, Takei N, Shimazu K, Christ L, Lu B, Chuang D-M. Lithium Induces Brain-derived Neurotrophic Factor and Activates TrkB in Rodent Cortical Neurons: An Essential Step for Neuroprotection against Glutamate Excitotoxicity. Neuropharmacology, 43:1173-1179, 2002.12 doi.org/10.1016/S0028-3908(02)00217-4
  23. Chuang D-M, Chen RW, Chalecka-Franaszek E, Ren M, Hashimoto R, Senatorov V, Kanai H, Hough C, Hiroi T, Leeds P. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar disorder, 4:129-136, 2002.4 
  24. Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang D-M, Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J Neurochem, 80:589-597, 2002.2 DOI: 10.1046/j.0022-3042.2001.00728.x
  25. Hashimoto R, Nakamura Y, Imamura K, Nakadate K, Kashiwagi Y, Matsumoto N, Takeda M. Visual stimulation-induced phosphorylation of neurofilament-L in the visual cortex of dark-reared rats. Eur J Neuroscience, 14(8):1237-1245, 2001.10 DOI: 10.1046/j.0953-816x.2001.01747.x
  26. Nakamura Y, Hashimoto R, Amano M, Nagata K, Matsumoto N, Goto T, Fukusho E, Mori H, Kashiwagi Y, Kudo T, Inagaki M, Takeda M. Localized phosphorylation of vimentin by Rho-kinase in neuroblastoma N2a cells. GENES TO CELLS, 5:823-837, 2000.10 DOI: 10.1046/j.1365-2443.2000.00372.x
  27. Hashimoto R, Nakamura Y, Koma, S, Kashiwagi Y, Matsumoto N, Shiosaka S, Takeda M. Phosphorylation of Neurofilament-L during LTD. Neuroreport, 11:2739-2742, 2000.8
  28. Hashimoto R, Nakamura Y, Komai S, Kashiwagi Y, Tamura K, Goto T, Aimoto S, Kaibuchi K, Shiosaka S, Takeda M. Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin dependent protein kinase II in the apical dendrites during long-term potentiation. J Neurochem, 75:373-382, 2000.7 DOI: 10.1046/j.1471-4159.2000.0750373.x
  29. Kudo T, Mima T, Hashimoto R, Morihara T, Tanimukai H, Tujio I, Nakamura Y, Mori K, Takeda M. Tau protein is a potential biological marker for normal pressure hydrocephalus. Psychiatry Clin Neurosci, 54:199-202, 2000.4
  30. Nakamura Y, Hashimoto R, Kashiwagi Y, Aimoto S, Fukusho E, Matsumoto N, Kudo T, Takeda M. Major phosphorylation site ( Ser-55 ) of neurofilament L by cyclic AMP dependent protein kinase A in rat primary neuronal culture. J Neurochem, 74:949-959, 2000.3 DOI: 10.1046/j.1471-4159.2000.0740949.x
  31. Kametani F, Nakamura Y, Tanaka K, Hashimoto R, Takeda M. Semiquantitative analysis of amyloid beta peptides using a combination of immunoprecipitation and matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. Anal Biochem, 275:262-265, 1999.11 doi.org/10.1006/abio.1999.4330
  32. Hashimoto R, Nakamura Y, Tujio I, Tanimukai H, Kudo T, Takeda M. Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system. Psychiatry Clin Neurosci, 53:587-591, 1999.10
  33. Hashimoto R, Nakamura Y, Kosako H, Amano M, Kaibuchi K, Inagaki M, Takeda M. Distribution of Rho-kinase in the bovine brain. Biochem Biophys Res Commun, 263(2):575-579, 1999.9 doi.org/10.1006/bbrc.1999.1409
  34. Nakamura Y, Hashimoto R, Kashiwagi Y, Wada Y, Sakoda S, Miyamae Y, Kudo T, Takeda M. Casein kinase II is responsible for phosphorylation of NF-L at Ser-473. FEBS Lett, 455(1-2):83-86, 1999.7 doi.org/10.1016/S0014-5793(99)00832-7
  35. Tanimukai H, Tsujio I, Hashimoto R, Kudo T, Kamino K, Shinozaki K, Takeda M. Presenilin-2 mutation and polymorphism In Japanese Alzheimer disease patients. Clinica Chimica Acta, 283:57-61, 1999.5
  36. Hashimoto R, Nakamura Y, Goto H, Wada Y, Sakoda S, Kaibuchi K, Inagaki M, Takeda M. Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase. Biochem Biophys Res Commun, 245:407-411, 1998.4 doi.org/10.1006/bbrc.1998.8446
  37. Kashiwagi Y, Nakamura Y, Miyamae Y, Hashimoto R, Takeda M. Pulse exposure of cultured neurons to aluminum-maltol affected axonal transport system. Neurosci Lett, 252(1): 5-8, 1998.8 doi.org/10.1016/S0304-3940(98)00505-9
  38. Nakamura Y, Hashimoto R, Kashiwagi Y, Miyamae Y, Shinozaki K, Nishikawa T, Hattori H, Kudo T, Takeda M. Abnormal distribution of neurofilament L in neurons with Alzhimer's disease. Neurosci Lett, 225:201-204, 1997.4 doi.org/10.1016/S0304-3940(97)00223-1
大阪大学大学院大阪大学・金沢大学・浜松医科大学・千葉大学・福井大学連合小児発達学研究科附属
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